The Rev. Edward Stone's letter to England's Royal Society in 1763 eventually earned billions for a German dye manufacturing company, the result of an unintended consequence.
It seems that Rev. Stone, seeking relief from various "agues" caused by "miasma" (bad air) from wet or swampy areas, happened to peel off and gnaw on a piece of willow bark as he wandered around the wetlands of Chipping Norton. In his mind was the common belief of the time that Divine Providence should supply a cure alongside the source of human ailments.